Last night I received an email from an agent who asked enthusiastically for my full, having read the partial. I sent the full, and spent today digging through her blog archive--and I just found an old post in which she states that she's the wrong agent to handle stories which feature two specific story elements that my novel happens to feature.

In other ways she'd be a great fit for this manuscript, and
maybe she'll love it enough to overlook those two particular elements, but my hopes of getting a positive reply are now just about dashed.